MAPT

MAPT
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1I8H, 4GLR, 2ON9, 3OVL, 4E0M, 4E0N, 4E0O, 4FL5, 4NP8, 2MZ7, 4TQE, 4Y5I, 4Y32, 5DMG, 4Y3B, 5HF3, 5E2W, 5E2V
Identifikatori
Aliasi	MAPT
Vanjski ID-jevi	OMIM: 157140 MGI: 97180 HomoloGene: 74962 GeneCards: MAPT
Lokacija gena (čovjek) Hrom. Hromosom 17 (čovjek)[1] Bend 17q21.31 Početak 45,894,527 bp[1] Kraj 46,028,334 bp[1]
Lokacija gena (miš) Hrom. Hromosom 11 (miš)[2] Bend 11 67.79 cM|11 E1 Početak 104,231,390 bp[2] Kraj 104,332,090 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • apolipoprotein binding • SH3 domain binding • vezivanje tubulina • GO:0001948, GO:0016582 vezivanje za proteine • lipoprotein particle binding • vezivanje enzima • vezivanje sa DNK • actin binding • microtubule binding • dynactin binding • receptor ligand activity • protein phosphatase 2A binding • Hsp90 protein binding • minor groove of adenine-thymine-rich DNA binding • double-stranded DNA binding • single-stranded DNA binding • vezivanje sa RNK • protein kinase binding • protein-macromolecule adaptor activity • phosphatidylinositol binding • vezivanje identičnih proteina • protein homodimerization activity • sequence-specific DNA binding • chaperone binding • histone-dependent DNA binding • microtubule lateral binding • phosphatidylinositol bisphosphate binding Ćelijska komponenta • citoplazma • cell body • projekcija ćelije • nuclear periphery • growth cone • neurofibrillary tangle • ćelijska membrana • tubulin complex • dendrit • cytoplasmic ribonucleoprotein granule • citoskelet • jedro • citosol • Mikrotubula • microtubule associated complex • membrana • nuclear speck • Akson • somatodendritic compartment • neuronal cell body • axon cytoplasm • extracellular region • intracellular anatomical structure • mitohondrija • microtubule cytoskeleton • axolemma • neuron projection • dendritična kičma • main axon • Lipidni splav • glial cell projection Biološki proces • generation of neurons • regulation of autophagy • regulation of microtubule polymerization • positive regulation of microtubule polymerization • positive regulation of axon extension • microtubule cytoskeleton organization • microglial cell activation • activation of cysteine-type endopeptidase activity involved in apoptotic process • GO:0072468 Transdukcija signala • Memorija • negative regulation of mitochondrial membrane potential • axonal transport of mitochondrion • cytoplasmic microtubule organization • neuron projection development • positive regulation of superoxide anion generation • negative regulation of kinase activity • cellular response to heat • astrocyte activation • intracellular distribution of mitochondria • synapse organization • regulation of calcium-mediated signaling • protein complex oligomerization • plus-end-directed organelle transport along microtubule • regulation of mitochondrial fission • negative regulation of mitochondrial fission • axonal transport • regulation of cellular response to heat • positive regulation of neuron death • positive regulation of protein localization to synapse • neurofibrillary tangle assembly • negative regulation of establishment of protein localization to mitochondrion • positive regulation of diacylglycerol kinase activity • regulation of response to DNA damage stimulus • internal protein amino acid acetylation • cell-cell signaling • response to lead ion • regulation of signaling receptor activity • negative regulation of gene expression • rRNA metabolic process • central nervous system neuron development • regulation of microtubule polymerization or depolymerization • regulation of chromosome organization • stress granule assembly • GO:0072353 cellular response to reactive oxygen species • microtubule polymerization • regulation of synaptic plasticity • axon development • regulation of microtubule cytoskeleton organization • supramolecular fiber organization • regulation of long-term synaptic depression • positive regulation of protein localization • negative regulation of tubulin deacetylation • amyloid fibril formation • cellular response to nerve growth factor stimulus • cellular response to brain-derived neurotrophic factor stimulus Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	4137	17762
Ensembl	ENSG00000186868 ENSG00000276155 ENSG00000277956	ENSMUSG00000018411
UniProt	P10636	P10637
RefSeq (mRNK)	NM_001123066 NM_001123067 NM_001203251 NM_001203252 NM_005910 NM_016834 NM_016835 NM_016841 NM_001377265 NM_001377266 NM_001377267 NM_001377268	NM_001038609 NM_010838 NM_001285454 NM_001285455 NM_001285456
RefSeq (bjelančevina)	NP_001116538 NP_001116539 NP_001190180 NP_001190181 NP_005901 NP_058518 NP_058519 NP_058525 NP_001364194 NP_001364195 NP_001364196 NP_001364197	NP_001033698 NP_001272383 NP_001272384 NP_001272385 NP_034968 NP_001390904 NP_001390905 NP_001390906 NP_001390907 NP_001390908 NP_001390909 NP_001390910 NP_001390911 NP_001390912 NP_001390913 NP_001390916 NP_001390919 NP_001390921 NP_001390923 NP_001390925 NP_001390927 NP_001390928 NP_001390931 NP_001390933 NP_001390934 NP_001390935 NP_001390939 NP_001390940 NP_001390941 NP_001390943 NP_001390944 NP_001390945
Lokacija (UCSC)	Chr 17: 45.89 – 46.03 Mb	Chr 11: 104.23 – 104.33 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Tau proteini (ili τ proteini, prema grčkom slovu koje označava ovo ime) su grupa od šest visoko rastvorljivih proteinskih izoformi proizvedenih alternativnom preradom primarnog transkripta gena MAPT (mikrotubulski-asocirani protein tau).^[5][6] Prvenstvenu ulogu imaju u održavanju stabilnosti mikrotubula u aksonima i obiluju neuronima centralnog nervnog sistema (CNS). Manje su česti drugdje, ali se također eksprimiraju na vrlo niskim nivoima u CNS-ovim astrocitima i oligodendrocitima .^[7]

Povezani sa tau proteinima koji su odgovorni za patološka stanje i demencija nervnog sistema, kao što su Alzheimerova i Parkinsonova bolest^[8] Tau proteini postali su hiperfosforilirani nerastvorljivi agregati zvani neurofibrilskii sklopovi. Proteini tau identificirani su 1975. godine, kao termički stabilni proteini, neophodni za sastavljanje mikrotubula^[9][10] > i od tada su okarakterizirani kao suštinski poremećeni proteini.^[11]

1. ^ ^{a b c} ENSG00000276155, ENSG00000277956 GRCh38: Ensembl release 89: ENSG00000186868, ENSG00000276155, ENSG00000277956 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000018411 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Goedert M, Wischik CM, Crowther RA, Walker JE, Klug A (juni 1988). "Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau". Proceedings of the National Academy of Sciences of the United States of America. 85 (11): 4051–5. Bibcode:1988PNAS...85.4051G. doi:10.1073/pnas.85.11.4051. PMC 280359. PMID 3131773.
6. ^ Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA (oktobar 1989). "Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease". Neuron. 3 (4): 519–26. doi:10.1016/0896-6273(89)90210-9. PMID 2484340. S2CID 19627629.
7. ^ Shin RW, Iwaki T, Kitamoto T, Tateishi J (maj 1991). "Hydrated autoclave pretreatment enhances tau immunoreactivity in formalin-fixed normal and Alzheimer's disease brain tissues". Laboratory Investigation; A Journal of Technical Methods and Pathology. 64 (5): 693–702. PMID 1903170.
8. ^ Lei P, Ayton S, Finkelstein DI, Adlard PA, Masters CL, Bush AI (novembar 2010). "Tau protein: relevance to Parkinson's disease". The International Journal of Biochemistry & Cell Biology. 42 (11): 1775–8. doi:10.1016/j.biocel.2010.07.016. PMID 20678581.
9. ^ Weingarten MD, Lockwood AH, Hwo SY, Kirschner MW (maj 1975). "A protein factor essential for microtubule assembly". Proceedings of the National Academy of Sciences of the United States of America. 72 (5): 1858–62. Bibcode:1975PNAS...72.1858W. doi:10.1073/pnas.72.5.1858. PMC 432646. PMID 1057175.
10. ^ Cleveland DW, Hwo SY, Kirschner MW (oktobar 1977). "Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin". Journal of Molecular Biology. 116 (2): 207–25. doi:10.1016/0022-2836(77)90213-3. PMID 599557.
11. ^ Cleveland DW, Hwo SY, Kirschner MW (oktobar 1977). "Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly". Journal of Molecular Biology. 116 (2): 227–47. doi:10.1016/0022-2836(77)90214-5. PMID 146092.